SlickRun is a free floating command line utility for Windows. SlickRun gives you almost Instant Access to any program or website. SlickRun allows you to create command aliases (known as MagicWords), so C:/Program Files/Outlook Express/msimn.exe becomes MAIL.
Enter a web URL into SlickRun and it will launch your browser and navigate to the specified address. Run multiple programs in a few keystrokes, jot a note, look up a definition... SlickRun is the most natural way to interact with your computer.
Please note, SlickRun is not a "HotKey" program. If you want a program that lets you press some wacky Keyboard Shortcut (say, Shift + Win + 1) to run to something, you'll want to find a different utility. SlickRun is designed to be far more intuitive than "hotkey" programs-- You shouldn't have to keep an awkward mental list of hotkeys for launching your favorite programs. Instead, just type whatever's most natural for you to remember; with auto-completion, you'll rarely type more than 2 or 3 characters anyway. Studies have shown that user-defined imperative words are much easier to recall than arbitrary characters like keystrokes.